Biological tissues are made up of different cell types arranged in specific patterns, which are essential to their proper ...

Capturing spatial information is essential to elucidate how cells function and interact within their native tissue environment. However, the initial spatial transcriptomics techniques have several ...

Scientists at Duke-NUS Medical School have developed two powerful computational tools that could transform how researchers study the "conversations" between cells inside the body. The tools, called ...

Spatial transcriptomics is a cutting-edge technique that characterizes gene expression within sections of tissue, such as heart, skin or liver tissue. These snapshots provide insights into how spatial ...

Immune low-response states significantly impact the effectiveness of immunotherapy in cancer treatment. These states ...

Biological systems are inherently three-dimensional—tissues form intricate layers, networks, and architectures where cells interact in ways that extend far beyond a flat plane. To capture the true ...

“If you have a machine—for example, a bike—all the different components of the bike would need to be fit in the right places for them to function,” said Lambda Moses, a computational biologist at ...

The liver is remarkable for its ability to regenerate after injury, yet when this process fails, acute liver failure (ALF) carries devastating outcomes. Traditional research methods, reliant on bulk ...

This eBook cuts through the complexity of spatial techniques, featuring a series of interviews with pioneers in the field, and peer-reviewed research from the Taylor & Francis journal portfolio. This ...

Initially, cells are dissociated from liver tissues into single-cell suspensions using in vivo enzymatic perfusion or ex vivo digestion methods. The cells of interest are then enriched from the ...