Cancer cells rapidly adapt to treatments, developing resistance that makes chemotherapy less effective. Researchers used an existing anti-inflammatory drug to disrupt cancer cells’ ability to adapt by ...

Cancer researchers have long treated genetic chaos and epigenetic rewiring as separate engines of disease, two parallel ...

Aging is accompanied by widespread epigenetic reprogramming, including the loss of heterochromatin and altered chromatin-associated processes. These changes compromise transcriptional precision and ...

In a wholly new approach to cancer treatment, Northwestern University biomedical engineers have doubled the effectiveness of chemotherapy in animal experiments. Instead of attacking cancer directly, ...

This work delineates how Setd2-mediated epigenetic reprogramming overcomes developmental barriers in cloned embryos. Comparative analysis revealed that SCNT embryos exhibit excessive H3K4me3 and ...

Metabolic reprogramming in the tumor microenvironment shapes immune function and therapy resistance, offering insights into ...

A mechanism by which knockouts of maternal mRNA clearing factors lead to zygotic arrest in mice. Abnormal accumulation of maternal mRNAs in mouse zygotes leads to transcriptional leakage before the ...

"Manipulating the H3.3 pathway may provide a way to completely wipe a cell's ‘memory’ and produce a truly pluripotent cell,” geneticist Steven Henikoff, from the Fred Hutchinson Cancer Research Center ...