49ers thrash Colts behind Purdy’s 5 TD passes: Live updates and reaction from NFL ‘Monday Night Football’

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage yards and caught two touchdowns, while George Kittle totaled seven receptions for 115 yards and a TD before leaving the game with an ankle injury.

Watch the 49ers vs Colts NFL game streaming free; Monday Night Football spread, start time

Phillip Rivers leads the Indianapolis Colts against Brock Purdy and the San Francisco 49ers tonight in this NFL Week 16 showdown.

Colts' Injury Issues Persist, Lose Promising Center vs. 49ers

The Indianapolis Colts have lost starting center Tanor Bortolini for the rest of the game against the San Francisco 49ers in a 'gotta have it' battle.
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49ers vs. Colts highlights: SF extends win streak to 5 games

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the highlights.

NFL expert picks today against the spread: Indianapolis Colts go with Philip Rivers again

The Indianapolis Colts are going with 44-year-old quarterback Philip Rivers again. The San Francisco 49ers are battling for NFC playoff position.