The Colts’ Monday night loss to the 49ers is the Bills’ gain. And the Jaguars’. And the Chargers’. All three teams have officially clinched playoff berths, as a result of the 49ers beating Indianapolis, 48-27.

The Colts don't just need to beat the Jaguars to keep their minuscule playoff hopes alive. They'll need some help. A lot of it, actually.

Expect plenty more NFL betting chaos to come this week and through the rest of the season, but this late in the season, always be mindful of motivation when looking at lines, especially early in the week. Let's dive into some early Week 17 plays. Bet on the Lions to cover with the DraftKings promo code:

The 49ers have arguably the toughest two-game closing stretch among the teams in playoff positions. They face the Chicago Bears in Week 17 and then take on the Seattle Seahawks in Week 18. The Seattle-San Francisco regular-season finale could be the No. 1 overall seed in the NFC and the NFC West title.

All the major storylines entering Week 16 with playoff scenarios aplenty. Get the latest NFL news and opinion at DAZN News

The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will be remembered as the Brock Purdy game. The 49ers quarterback powered San Francisco to a 48-27 road victory with a career-high five passing touchdowns.

The Packers can clinch a playoff spot with the win over the Ravens on Saturday after Aaron Rodgers and the Steelers knocked off the Lions on Sunday.