Fragment-based drug design is a new approach that has been successfully applied to challenging targets, such as protein-protein interactions. While 3-D protein structures have been used in drug ...

Fragment-based drug discovery is gaining momentum as an efficient strategy to find and optimize leads. The technology first identifies small chemical fragments that bind weakly, yet efficiently, to ...

New research published in Science Advances provides a template for how to develop directly-acting antivirals with novel modes of action, that would combat COVID-19 by suppressing the SARS-CoV-2 viral ...

Cancer, diabetes, inflammation, malaria. The list of diseases ripe for new treatments is long. Yet the pace of drugs coming to market is actually flat. A key reason is the drug discovery process ...

With help from artificial intelligence, MIT researchers have designed novel antibiotics that can combat two hard-to-treat infections: drug-resistant Neisseria gonorrhoeae and multi-drug-resistant ...

The path leading to successful drug discovery in the twenty-first century comprises many routes, some of which lead to dead ends or are unpromising. Careful planning and navigation are the keys to ...

New approaches are essential to deliver drugs and tool compounds against increasingly difficult targets. Rather than screening millions of drug-sized compounds, fragment-based drug discovery starts ...

The Institute of Cancer Research and Enamine Ltd. have announced a new research collaboration aimed at broadening the tools available for researchers working in fragment-based drug discovery (FBDD).

Mass spectrometers are high-tech machines that play an important role in our society. They are highly sensitive analytical instruments that are indispensable in areas such as medical diagnostics, food ...

Developing new ways to break and reform chemical bonds is one of the main tasks of basic chemical research. “When a bond in a charged molecule is broken, the result is often a chemically ‘aggressive’ ...