A study by Duke-NUS Medical School has found that members of the multiprotein 'Integrator complex', known for its role in gene regulation, are crucial for healthy brain development in fruit flies. The ...

Ectopic neural stem cells are formed upon loss of the Integrator S5 gene in the brain. Single neural stem cell lineages are marked by CD8-GFP and white dotted lines. Type II neural stem cells, ...

Gene expression is a highly regulated process, which involves several steps. These include transcription of DNA instructions into RNA, removal of non-coding segments from the RNA message, and its ...

SINGAPORE, 24 April 2019 - A study by Duke-NUS Medical School has found that members of the multiprotein 'Integrator complex', known for its role in gene regulation, are crucial for healthy brain ...

Failure of a gene-reading quality-control mechanism called Integrator leaves cells littered with abnormal RNA strands that increase cell stress and may contribute to diseases such as cancer and ...

Researchers from the Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, say they have discovered a new checkpoint mechanism that fine-tunes gene ...

Alternative splicing aids in maintaining the complexity of the transcriptome in higher organisms, and small nuclear RNAs (snRNAs), which are major components of the spliceosome, are processed by the ...