Disrupting maternal gut-immune axis perturbed immune networks in developing mouse brains, revealing potential mechanisms underlying neurodevelopmental disorders.

The maternal microbiome and immune system have both independent and synergistic effects on fetal brain health - changes in ...

The maternal microbiome and immune system have both independent and synergistic effects on fetal brain health—changes in the ...

While such advances bring with them a breadth of knowledge, the immense complexity of the datasets makes it challenging for scientists to analyze them using current computational methods. Now, ...

Certain cells in the brain create a nurturing environment, enhancing the health and resilience of their neighbors, while others promote stress and damage. Using spatial transcriptomics and AI, ...

Biological tissues are made up of different cell types arranged in specific patterns, which are essential to their proper ...

Spatial transcriptomics provides a unique perspective on the genes that cells express and where those cells are located. However, the rapid growth of the technology has come at the cost of ...

Dr. Xuyu Qian in his current laboratory, standing beside a collection of external hard drives containing raw spatial transcriptomics data from his groundbreaking human brain development research. The ...

This figure shows how the STAIG framework can successfully identify spatial domains by integrating image processing and contrastive learning to analyze spatial transcriptomics data effectively.