The most important game of the weekend might actually occur in Las Vegas in a game that could have massive ramifications for the 2026 draft.

Daily Fantasy multimillionaire Mike McClure reveals his daily Fantasy football picks for Indianapolis vs. San Francisco on 'MNF'

The Denver Broncos and Kansas City Chiefs clash Christmas night. Kickoff for Thursday Night Football is at 8:15 p.m. ET in Kansas City, Missouri.

Denver clinches the West with a win against the Chiefs and a Chargers loss to the Texans. Mike Florio and Chris Simms thinks things could get ugly in Kansas City during Week 17 with what should be an angry Broncos team.

DFS millionaire Mike McClure shares his NFL DFS picks for Cowboys vs. Commanders, Lions vs. Vikings and Chiefs vs. Broncos on Christmas Day 2025