Nature

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

The alternative text for this image may have been generated using AI. Figure 2: After peripheral administration, 10D5 and 3D6 enter the CNS, bind to Aβ plaques and trigger amyloid clearance. The ...
Nature

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

The alternative text for this image may have been generated using AI. Figure 3: Species-specific cleavage of APP at the +11 site of Aβ. The alternative text for this image may have been generated ...