Targeted Oncology

Choosing First-Line CLL Therapy in a Patient With Del(17p), TP53

The AMPLIFY study [NCT03836261] did not include patients with del (17p), so that doublet is not relevant. The study that used ...
The New England Journal of Medicine

A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia

MicroRNA expression profiles can be used to distinguish normal B cells from malignant B cells in patients with chronic lymphocytic leukemia (CLL). We investigated whether microRNA profiles are ...
ascopubs.org

Improved Interpretability of Machine Learning Model Using Unsupervised Clustering: Predicting Time to First Treatment in Chronic Lymphocytic Leukemia

A total of 737 treatment-naïve patients with CLL diagnosed at Mayo Clinic were included in this study. We compared predictive abilities for two survival models (Cox proportional hazards and random ...
mp.pl

A novel method of diagnosing and monitoring cardiac arrhythmias in patients with chronic lymphocytic leukemia treated with ibrutinib

Chronic lymphocytic leukemia (CLL) is the most common leukemia in adult patients living in the western hemisphere. The annual incidence of CLL is 4.2/100 000 people, with median (interquartile range ...