Astrocytes, the Gatekeepers of Norepinephrine Signaling in the Brain ...
Jun 6, 2025 · Norepinephrine modulates neuronal synapses by way of astrocyte adrenergic receptors. The astrocytes release ATP, which converts to adenosine, a neuromodulator that binds nearby …
Astrocytes Mount Complex Responses to AD. They Change Over Time
Dec 5, 2024 · This is an impressive study by Serrano-Pozo, Hyman, Das and colleagues that explores astrocyte transcriptomic molecular programs in aging and Alzheimer’s Disease. Using single-nucleus …
Alleviating symptoms of neurodegenerative disorders by astrocyte ...
Oct 4, 2023 · The development of an adeno-associated virus (AAV)-mediated strategy for astrocyte-specific overexpression of TMEM164 offers a novel therapeutic target and approach for treating …
Latest From GNPC: APOE4 Ages Astrocytes, Cripples Energy Metabolism
Astrocyte Age Affects APOE’s Impact. Having extremely young (left) or normally aged (middle) astrocytes blunts the ill effects of one (yellow) or two (orange) E4 alleles, while extremely old (right) …
GPCR signaling gates astrocyte responsiveness to neurotransmitters …
Jun 6, 2025 · Collectively, these papers highlight the critical and diverse roles of astrocytes in mediating the effects of norepinephrine, and related neuromodulators such as tyramine and octopamine, on …
Astrocyte reactivity influences amyloid-β effects on tau ... - ALZFORUM
Jun 2, 2023 · Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease. Nat Med. 2023 Jul;29 (7):1775-1781. Epub 2023 May 29 PubMed.
Transcriptomics Paint Astrocytes as Source of Cognitive Resilience
Jul 26, 2024 · Transcriptomics study surveyed six brain regions in people with or without AD. Reelin-expressing neurons were less abundant in AD. Vulnerable neurons in different brain regions were …
“iAssembloids” Probe Glial Roles in Neuron Survival | ALZFORUM
Jan 24, 2025 · To learn what astrocyte ApoE4 might be doing, the scientists compared iAssembloids in which astrocytes expressed ApoE4 with those containing astrocytes that produced ApoE3. More …
Perineuronal Pockets Prevent Spillage from Synapses - ALZFORUM
Jul 23, 2024 · In wild-type mice, tiny pockets in this perineuronal net give astrocytes access to interneuron synapses, the authors report. The pockets also corralled glutamate and other signaling …
In Amyloidosis, EphA4 Goads Astrocytes to Massacre Synapses
Mar 7, 2025 · EphA4 inhibition counteracted both astrocyte reactivity and synaptic engulfment. EphA4 expression rose in both neurons and astrocytes with worsening amyloidosis, but was neuronal or …